Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma

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Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma.

The insulin-like growth factor (IGF) signaling pathway is involved in cell proliferation and differentiation. Elevated serum IGF1 levels have been associated with increased colorectal cancer risk; however, studies of this association with colorectal adenoma are inconclusive. We examined serum IGF1, IGF2 and IGFBP3 levels in relation to risk of advanced colorectal adenoma in a case-control study...

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Author affiliations: Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States; Department of Epidemiology,...

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ژورنال

عنوان ژورنال: International Journal of Cancer

سال: 2011

ISSN: 0020-7136

DOI: 10.1002/ijc.26438